The British Broadcasting Corporation has long used Perl, but:
For applications that run internally we use Ruby on Rails. Because we enjoy using it, it's fast to develop with, straight forward to use and because we use it (i.e. to reduce knowledge transfer and training requirements) we decided to follow the same design patterns and coding conventions used in Rails when we built our MVC framework. Yes that's right we've built Perl on Rails.
I know Curtis "Ovid" Poe is working for the BBC now, so here's hoping some of that Railsy goodness comes back to feed the community. The BBC already has 17 distributions on the CPAN.