The schedule for YAPC::NA just got published, and there's plenty of good stuff this year. If you haven't decided to make the trip out to Chicago June 16-18 yet, this should help.
Cool stuff that jumps out at me as I peruse the grid: JT Smith talking about the premade application stack that WebGUI uses, Schwern on testing data with The Sims, and Kevin Falcone on timezone handling.
For the beginners, Kent Cowgill's intro to testing is a great way to get introduced to the topic, and I'm sure that Leonard Miller talking about Perl::Tidy and Perl::Critic will help instill good coding practices.
Do you have recommendations on must-see talks? Let your fellow Perlbuzz readers know in the comments below.